Understanding Space: the nascent synthesis of cognition and the syntax of spatial morphologies

24-28 September, 200

Perceptions of Building-layout Complexity

This poster presents an experiment on judgments of design complexity, based on two modes of stimuli: the layouts of corridor systems in buildings shown in plan view and movies of simulated walkthroughs. Randomly selected stimuli were presented to 166 subjects: ‘experts’ (architects or students currently enrolled on an architectural course) and ‘lay people’ (all others). The aims were to investigate whether there were differences between these two groups in terms of their judgments of building complexity, effects of modality of stimuli and if any environmental measures (geometric or complexity-based) correlated with the assessments. The results were, first, there are differences between the judgments of the experts and non-experts, second, the effect of modality was negligible for lay people but evident for the ‘experts’, third, the judgments of both groups correlated highly with a number of environmental measures

Turning the shelves: empirical findings and space syntax analyses of two virtual supermarket variations

The spatial structure of a virtual supermarket was systematically varied to investigate human behavior and cognitive processes in unusual building configurations. The study builds upon experiments in a regular supermarket, which serve as a baseline case. In a between-participant design a total of 41 participants completed a search task in two different virtual supermarket environments. For 21 participants the supermarket shelves were turned towards them at a 45° angle when entering the store, giving high visual access to product categories and products. For 20 participants the shelves were placed in exactly the opposite direction obstructing a quick development of shopping goods dependencies. The obtained differences in search performance between the two conditions are analyzed using space syntax analyses and comparisons made of environmental features and participants’ actual search path trajectories

Navigating complex buildings: cognition, neuroscience and architectural design

This paper is in two sections, the first section presents a review of recent research in the areas of neuroscience, cognitive science and architecture with particular respect to what is currently understood about how buildingusers find their way around complex buildings. It goes on to define four areas of promising, potential future research located on the boundaries between these three disciplines, these being: spatial knowledge acquisition, orientation, multilevel environments and environment intelligibility. In the second half of the paper, it suggests how such current research and/or any future program of research could be used to aid architects in the design of new buildings. One such method suggested is the creation of designguidelines or heuristics based upon research into navigation and wayfinding. The paper concludes with an example list of eight sample guidelines

Getting lost in buildings

People often get lost in buildings, including but not limited to libraries, hospitals, conference centers, and shopping malls. There are at least three contributing factors: the spatial structure of the building, the cognitive maps that users construct as they navigate, and the strategies and spatial abilities of the building users. The goal of this article is to discuss recent research on each of these factors and to argue for an integrative framework that encompasses these factors and their intersections, focusing on the correspondence between the building and the cognitive map, the completeness of the cognitive map as a function of the strategies and individual abilities of the users, the compatibility between the building and the strategies and individual abilities of the users, and complexity that emerges from the intersection of all three factors. We end with an illustrative analysis in which we apply this integrative framework to difficulty in way-finding

Interaction and architectural space

For many in the field of HCI, location and space are synonymous; yet, as we move from the mobile era to the ubiquitous era, computing becomes entangled with notions of space. This workshop critically examines the role of space in human-computer interfaces. The objective is to bring together diverse perspectives of space, drawing from architecture, philosophy, art, geography, design, dance, spatial-cognition, mathematics, computing, and still other domains, towards foregrounding space in theoretical discussions and explorations within the CHI community. Expected outcomes are the reporting of fresh insights into the impact and role of space in the interaction process

Diagnostic performance of the AID line probe assay in the detection of Mycobacterium tuberculosis and drug resistance in Romanian patients with presumed TB.

BACKGROUND: The AID line probe assay has shown promising evaluation data on the detection of Mycobacterium tuberculosis as well as 1st- and 2nd-line drug resistance, using isolates and selected clinical samples in previous studies. METHODS: The diagnostic performance of three AID-modules (AID INH/RIF, AID FQ/EMB and AID AG) was analyzed in sputum samples from patients with presumed tuberculosis against culture methods and phenotypic drug resistance as reference standards.Results59 patients had culture-confirmed tuberculosis. All AID modules showed moderate sensitivity (46/59, 78.0%, 65.3-87.7) and very good specificity (100%, 95.5%, 93.7%). There was a high proportion of invalid tests, resulting in 32.6%, 78.3% and 19.6% of 46 AID-positive tuberculosis cases, who could not be assessed for drug resistance by the AID INH/RIF-, AID FQ/EM- and AID AG-module, respectively. A small number of patients showed drug resistance by reference standards: Three MDR-TB cases plus three, one and one patients with resistance to streptomycin, fluoroquinolones and aminoglycosides, respectively. The AID-assay detected all MDR-TB cases, two of three streptomycin-resistant TB cases, one of one of fluoroquinolone-resistant and missed one aminoglycoside-resistant TB case. DISCUSSION: The high proportion of invalid results precludes the use of the AID-assay from direct sputum-based tuberculosis and drug-resistance testing

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

The antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent development of pneumonic COVID-19. However, the protective immunological response associated with successful viral containment in the upper airways remains unclear. Here, we combine a multi-omics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associate specific immune trajectories with upper airway viral containment. We see a distinct systemic rather than local immune state associated with viral containment, characterized by interferon stimulated gene (ISG) upregulation across circulating immune cell subsets in non-pneumonic SARS-CoV2 infection. We report reduced cytotoxic potential of Natural Killer (NK) and T cells, and an immune-modulatory monocyte phenotype associated with protective immunity in COVID-19. Together, we show protective immune trajectories in SARS-CoV2 infection, which have important implications for patient prognosis and the development of immunomodulatory therapies